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Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?
Sponsor: University of Aarhus
Summary
Aim To investigate the effects of oral lactate administration on nutrient absorption and substrate utilization in individuals with pre-diabetes. Hypothesis The addition of lactate to a meal improves postprandial lipemia and reduces lipid storage in ectopic tissues through delayed absorption and faster removal of circulating lipids from circulation.
Key Details
Gender
All
Age Range
50 Years - Any
Study Type
INTERVENTIONAL
Enrollment
25
Start Date
2024-08-22
Completion Date
2026-01
Last Updated
2025-06-19
Healthy Volunteers
Yes
Conditions
Interventions
Placebo + mixed meal
Placebo (140 mL isoosmotic salt water, NaCl) given 30 minutes before a liquid test meal with the addition of 70 MBq 18F-FTHA = CTR
Lactate + mixed meal
Lactate (140 mL lactate drink = 25 g D/L-lactate bound to Na) given 30 minutes before a liquid test meal with the addition of 70 MBq 18F-FTHA = LAC The investigators will also use the 18F-FTHA standardized uptake value (SUV) to evaluate dietary fatty acid trapping and distribution, to be able to compare our results with former studies using the 18F-FTHA method.
PET-scan
Dynamic whole-body PET scan.
Mixed meal with 18F-FTHA
Mixed meal test with the addition of 70 MBq 18F-FTHA
Locations (1)
Aarhus University Hospital
Aarhus, Denmark