Clinical Research Directory
Browse clinical research sites, groups, and studies.
Corticosteroids for Post-Extubation Dysphagia
Sponsor: University of Colorado, Denver
Summary
This is a placebo-controlled, double-blind randomized trial of a short course of intravenous corticosteroids for Acute Respiratory Failure Survivors with Fiberoptic Endoscopic Evaluation of Swallowing (FEES) documented laryngeal edema. Study was leveraged using the existing R01 grant infrastructure COMIRB # 21-3873, study design, and research methods. Patients for the study proposed will have already been enrolled in the R01 longitudinal cohort study. The sites to perform this study include Colorado, BU, Yale, and Stanford. Those R01-enrolled patients with laryngeal edema on their initial FEES examination: defined as the revised Patterson edema score greater than zero, will be approached for enrollment.
Official title: Randomized Trial of Corticosteroids for Post-Extubation Aspiration
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2024-11-13
Completion Date
2027-05-31
Last Updated
2024-11-19
Healthy Volunteers
No
Conditions
Interventions
Methylprednisolone
50 mg methylprednisolone IV every 6 hours for 4 doses to reduce laryngeal edema
Normal Saline
Normal Saline placebo IV every 6 hours for 4 doses
Locations (1)
University of Colorado
Aurora, Colorado, United States