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Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia - ToolCAP
Sponsor: University of Bern
Summary
The ToolCAP study aims to see if using ultrasound to look at the lungs when children have symptoms of a lung infection will safely allow doctors to improve how they treat those infections. The study will also look at if it's possible to improve how doctors decide which children need antibiotics. * Lung infections are the most common reason for children to go to the clinic/hospital. * Doctors usually give an antibiotic to every child with a lung infection. * Lung infections can be caused by 2 different types of germs - bacteria or viruses. * Antibiotics only work against bacteria and not against viruses. Lung infections caused by viruses don't need antibiotics as the body fights them by itself. * Lots of research now shows that only 1 in 4 children with a lung infection actually needs an antibiotic, as the rest only have a viral infection causing the symptoms. * This means that 3 in 4 children get an antibiotic when they don't need it. * Taking too many antibiotics can cause problems for children as it can cause diseases like diabetes or asthma. * Nowadays, due to too many people using too many antibiotics, experts are starting to worry that bacteria are starting to become resistant (stronger than the antibiotic). * Ultrasound of the lungs appears to be a way of safely looking at the lungs to see if there is an infection and may help doctors better decide who needs an antibiotic. This study includes children aged 2 months-12 years who come to the hospital with a lung infection. Children who are very unwell or who have already had 2 days of antibiotic treatment will not be allowed to be in the study.
Official title: ToolCAP: Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia
Key Details
Gender
All
Age Range
60 Days - 12 Years
Study Type
INTERVENTIONAL
Enrollment
3500
Start Date
2025-04-04
Completion Date
2026-12
Last Updated
2025-06-18
Healthy Volunteers
No
Interventions
Lung ultrasound
Portable lung ultrasound
Standard of Care (SOC)
SOC antibiotic treatment
Locations (9)
Université Cheikh Anta Diop
Dakar, Senegal
Centre National Hospitalier d'Enfants Albert Royer
Dakar, Senegal
Centre De Santé Gaspard Kamara
Dakar, Senegal
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University
Parow, Cape Town, South Africa
University of Witwatersrand, MRC/Wits Rural Public Health and Health Transitions Research Unit
Parktown, Johannesburg, South Africa
Tintswalo Hospital
Acornhoek, Mpumalanga, South Africa
Themba Hospital
Mbombela, South Africa
Ifakara Health Institute
Ifakara, Morogoro, Tanzania
Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania