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RECRUITING
NCT06670833
NA

Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia - ToolCAP

Sponsor: University of Bern

View on ClinicalTrials.gov

Summary

The ToolCAP study aims to see if using ultrasound to look at the lungs when children have symptoms of a lung infection will safely allow doctors to improve how they treat those infections. The study will also look at if it's possible to improve how doctors decide which children need antibiotics. * Lung infections are the most common reason for children to go to the clinic/hospital. * Doctors usually give an antibiotic to every child with a lung infection. * Lung infections can be caused by 2 different types of germs - bacteria or viruses. * Antibiotics only work against bacteria and not against viruses. Lung infections caused by viruses don't need antibiotics as the body fights them by itself. * Lots of research now shows that only 1 in 4 children with a lung infection actually needs an antibiotic, as the rest only have a viral infection causing the symptoms. * This means that 3 in 4 children get an antibiotic when they don't need it. * Taking too many antibiotics can cause problems for children as it can cause diseases like diabetes or asthma. * Nowadays, due to too many people using too many antibiotics, experts are starting to worry that bacteria are starting to become resistant (stronger than the antibiotic). * Ultrasound of the lungs appears to be a way of safely looking at the lungs to see if there is an infection and may help doctors better decide who needs an antibiotic. This study includes children aged 2 months-12 years who come to the hospital with a lung infection. Children who are very unwell or who have already had 2 days of antibiotic treatment will not be allowed to be in the study.

Official title: ToolCAP: Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia

Key Details

Gender

All

Age Range

60 Days - 12 Years

Study Type

INTERVENTIONAL

Enrollment

3500

Start Date

2025-04-04

Completion Date

2026-12

Last Updated

2025-06-18

Healthy Volunteers

No

Interventions

OTHER

Lung ultrasound

Portable lung ultrasound

OTHER

Standard of Care (SOC)

SOC antibiotic treatment

Locations (9)

Université Cheikh Anta Diop

Dakar, Senegal

Centre National Hospitalier d'Enfants Albert Royer

Dakar, Senegal

Centre De Santé Gaspard Kamara

Dakar, Senegal

Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University

Parow, Cape Town, South Africa

University of Witwatersrand, MRC/Wits Rural Public Health and Health Transitions Research Unit

Parktown, Johannesburg, South Africa

Tintswalo Hospital

Acornhoek, Mpumalanga, South Africa

Themba Hospital

Mbombela, South Africa

Ifakara Health Institute

Ifakara, Morogoro, Tanzania

Muhimbili University of Health and Allied Sciences

Dar es Salaam, Tanzania