Clinical Research Directory

Inclusion Criteria: 1. Age 18 to 75 years old (inclusive), Female or male 2. Subjects with unresectable locally advanced or metastatic non-squamous non-small cell lung cancer confirmed by histology or cytology 3. Previously treated by EGFR-TKI； 4. At least one measurable tumor lesion according to RECIST v1.1 5. ECOG performance score of 0-1; 6. Expected survival time ≥ 12 weeks; 7. Adequate bone marrow and organ function 8. Subjects are required to give informed consent for this study prior to the trial and voluntarily sign a written informed consent form. Exclusion Criteria: 1. Subjects with active central nervous system (CNS) metastases. 2. Received antitumor therapy such as chemotherapy within 4 weeks prior to the first dose of study drug; 3. Received \>30 Gy of non-thoracic radical radiation therapy within 4 weeks prior to the first administration of study drug; 4. Major organ surgery or significant trauma within 4 weeks prior to first use of study drug; 5. Concomitant other malignancies ≤ 5 years prior to first dose of study drug; 6. Subjects with a history of interstitial pneumonitis or imaging at screening suggestive of suspected interstitial pneumonitis; or other moderate-to-severe lung disease that severely affects lung function 7. Serious cardiovascular disease 8. Presence of severe infection within 4 weeks prior to first dose of study drug 9. Arterial/venous thrombotic events within 3 months prior to the first study dose 10. History of immunodeficiency, including a positive HIV test 11. Presence of active hepatitis B or C; 12. History of allergic reactions to any component of study treatment or severe allergic reactions to other monoclonal antibodies.