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Intralesional Injection of STS in Treatment of Calcinosis
Sponsor: Robyn T. Domsic, MD, MPH
Summary
The specific objective of this study is to perform a small, open-label study to assess the safety and efficacy of intralesional, subcutaneous injection of STS on calcinosis symptoms and lesion size in systemic sclerosis (SSc), mixed connective tissue disease (MCTD) and dermatomyositis (DM) patients. Injection will be guided by ultrasound, lesion size assessed by ultrasound, and symptom burden by patient-reported outcome measures.
Official title: An Open Label Evaluation of Intralesional Injection of Sodium Thiosulfate in the Treatment of Cutaneous or Tendon Calcinosis in Connective Tissue Disease
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-03-17
Completion Date
2029-05-01
Last Updated
2025-09-08
Healthy Volunteers
No
Interventions
Sodium Thiosulfate (STS)
Depending on the size of the calcinosis lesion, 1-5ml of STS (250mg/ml) will be used for injection under ultrasound guidance.
Locations (1)
UPMC Arthritis and Autoimmunity Center
Pittsburgh, Pennsylvania, United States