Clinical Research Directory

Inclusion Criteria: * All patients presenting to ENT department will be subjected eligible Adults patients newly diagnosed at outpatient clinic with laryngeal cancer at any stage and will undergo total/partial laryngectomy surgery. Patients with Level of hemoglobin \>9 mg/dl and serum albumin 3g/dl According to (Crosetti et al. 2021). Staging of laryngeal cancer according to the American Joint Committee on Cancer (AJCC) 8th edition by TNM system. Exclusion Criteria: \- 1. Impaired renal function sr.cr≤2.5 (zinc clearance). 2.Previous history of cancer diseases in other sites( previous chemotherapy or radiation). 3.Hypersensitivity to probiotics and zinc.