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Diagnostics and Surveillance of Acute Meningo-encephalitis Among Children in Cambodia With a Focus on Japanese Encephalitis Virus
Sponsor: ANRS, Emerging Infectious Diseases
Summary
The primary objective of this study is to quantify the clinical burden of Japanese Encephalitis (JE) and the asymptomatic circulation of JEV among Cambodian children, through two pediatric cohorts: non-febrile children at recruitment and children hospitalized with febrile neurological syndrome (FNS). Secondary objectives include estimating anti-JEV seropositivity rates, identifying individual risk factors and living conditions associated with JEV infection, characterizing clinical and biological profiles related to disease severity, and evaluating the role of deficiencies in interferon (IFN) response in severe JEV infections.
Key Details
Gender
All
Age Range
2 Years - 14 Years
Study Type
OBSERVATIONAL
Enrollment
4000
Start Date
2025-10-15
Completion Date
2028-01
Last Updated
2025-09-11
Healthy Volunteers
Yes