Clinical Research Directory

Inclusion Criteria: * Acute (duration ≤14 days) fever (37.5°C or higher or a history of fever in the previous 24h) AND * Eschar OR * ≥ 2 of the following: * Living in rural parts of Chiangrai Province or other ST risk areas * History of outdoor risk activities in the 2 weeks before symptom onset * Presenting during the rainy season or early cold season * Two or more of: headache; myalgia, cough, abdominal symptoms (abdominal pain/ nausea-vomiting); myalgia; lymphadenopathy AND * ≥ 7 years old AND * Weight\>15Kg AND * The patient and/or where relevant their parent/guardian/caretaker/legally acceptable representative willing and able to give informed consent /assent for participation in the study AND Positivity to any of the screening tests (Immunochromatographic RDT or iiPCR) Exclusion Criteria: \- Other clear focus of infection (e.g. lobar pneumonia by chest x-ray, abscess) OR Other clear cause of fever (e.g. positive Dengue IgM or NS1 antigen, positive blood cultures, untreated HIV)