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RECRUITING
NCT06678516
NA

Intermittent Fasting on the Blood Microbiome

Sponsor: Erasmus Medical Center

View on ClinicalTrials.gov

Summary

The investigators previously demonstrated that the gut microbiome can be remodeled by one month of intermittent fasting (OMIF) in healthy volunteers and animal models, with a notable alteration observed in its overall composition which could be linked to improvement in liver function. The blood microbiome, which mirrors the human ecosystem and includes all microbes mainly including bacteria, archaea, and viruses, is a new-identified human microbiome assessment tool that is assumed to be more stable and representative than the gut microbiome, with substantial potential for the diagnosis and prediction of liver cirrhosis and cancer. However, the effect of OMIF, which mimics lifestyle change typically advised in liver disease, on this blood microbiome remains elusive at best. The aim of this study is to explore whether OMIF remodels the composition and function of the blood microbiome in healthy volunteers, through a Randomized controlled cross-over trial, with secondary outcomes on the association of blood microbiome with the gut microbiome.

Official title: The Effect of One Month of Intermittent Fasting on the Blood Microbiome in Healthy Volunteers

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

48

Start Date

2025-12-01

Completion Date

2026-01-10

Last Updated

2025-02-26

Healthy Volunteers

Yes

Conditions

Interventions

DIETARY_SUPPLEMENT

Intermittent fasting

Participants are asked to abstain from any form of fasting or calorie restriction in one month of the study (which is also a pre-fasting washout for those volunteers that might be performing forms of fasting before the study) and then start with one month of intermittent fasting, with daily fasting duration from 7:30 to 18:30. Food is abstained from during fasting, only water and zero-calorie drinks like black coffee and unsweetened tea are allowed.

Locations (2)

Northwest Minzu University

Lanzhou, Gansu, China

Erasmus Medical Center - Department of Gastroenterology and Hepatology

Rotterdam, Netherlands