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Hydrocortisone in Hormone Replacement Therapy for Large Pituitary Neuroendocrine Tumors
Sponsor: Beijing Tiantan Hospital
Summary
The goal of this clinical trial is to assess the need for hydrocortisone replacement therapy during the perioperative period for large pituitary neuroendocrine tumors. The main questions it aims to answer are: • Does hydrocortisone replacement therapy reduce the incidence of adrenal insufficiency in participants? Researchers will compare hydrocortisone to a placebo (a look-alike substance that contains no drug) to see if hydrocortisone works to reduce the incidence of adrenal insufficiency. Participants will: * Take or intravenous infusion drug hydrocortisone or a placebo every day for 2 weeks * Visit the clinic three months after surgery for checkups and tests * Keep a diary of their symptoms
Official title: Study on the Efficacy of Hydrocortisone in Perioperative Hormone Replacement Therapy for Large Pituitary Neuroendocrine Tumors:a Multicenter, Randomized, Double-blind, Placebo- Parallel Controlled Study
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
882
Start Date
2024-12-04
Completion Date
2026-06-30
Last Updated
2025-01-14
Healthy Volunteers
No
Interventions
Hormone replacement therapy
Perioperative Hydrocortisone Reduction Therapy
Placebo
Perioperative placebo Reduction Therapy
Locations (1)
Beijing, Beijing Tiantan Hospital,Capital Medical University
Beijing, Beijing Municipality, China