Clinical Research Directory

ICP-EXPOSED GROUP Inclusion Criteria: * mother with recent diagnosis of intrahepatic cholestasis of pregnancy (serum bile acids over 10 micromol/l in the last 7 days before birth), with informed consent given a few hours before giving birth * ursodeoxycholic acid, independent of dosage or initiation of treatment * neonates born in Clinical Hospital of Obstetrics and Gynecology "Prof.Dr. Panait Sirbu" or transferred to our unit in the first 24 hours of life Exclusion Criteria: * no informed consent * serum bile acids under 10 micromol/l in the last 7 days before birth * newborns transferred from other neonatal units after 24 hours of life UNEXPOSED GROUP Inclusion Criteria: * mother with no history of hepatic disease during or before the current pregnancy, with informed consent given a few hours before giving birth * neonates born in Clinical Hospital of Obstetrics and Gynecology "Prof.Dr. Panait Sirbu", of similar gestational age/weight/sex at birth to corresponding neonates in the ICP-exposed group Exclusion Criteria: \- ursodeoxycholic acid, independent of dosage or initiation of treatment (suspected hepatic disease/elevated transaminases)