Clinical Research Directory

Inclusion Criteria: * Adults aged 18 years to 50 years * The subject is in good general health with no evidence of any medical problems, * Fully vaccinated for COVID-19 * Fluent in both written and spoken English * Willing and able to provide informed consent, * Able to comply with study procedure. Exclusion Criteria: * Children (under the age of 18) * Adults above 50 years old * History of heart, lung, kidney, or liver disease. * Obesity (BMI \> 30), * Diagnosis of asthma, sleep apnea, or use of CPAP. * Diagnosis of Raynaud's disease * Unacceptable collateral circulation based on an exam by the investigator (Allen's test). * Pregnant, lactating or trying to get pregnant * Current smoker * History of diabetes * Clotting disorder * Hemoglobinopathy or history of anemia * History of fainting or vasovagal response * Any other serious systemic illness * Any other condition which, in the opinion of the investigators, would make them unsuitable for the study, * Any injury, deformity, or abnormality at the sensor sites that in the opinion of the investigators' would interfere with the sensors working correctly, * Any evidence, in the opinion of the investigators, of medical problems or poor general health * Any symptoms related to COVID-19 * No vaccinated for COVID-19 * Recent injection with methylene blue * History of reactions to medical adhesives, * Unable or unwilling to provide informed consent, * Inability to comply with the study procedure, * Non-English Speaker.