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Pharmaco-proteomic Platform to Evaluate Drug Interactions in Liver Transplant Patients
Sponsor: Pontificia Universidad Catolica de Chile
Summary
The goal of this observational study is to enhance the ability to forecast kidney failure in liver transplant patients in the ICU under multidrug treatment by developing a computer platform that integrates mathematical models of drug interactions, proteomics, and clinical data. The main outcomes it aims to develop are: 1. Design the multidrug web computing platform with available information on drug pair interactions (DDIs). 2. Integrate the proteomic and clinical data of liver transplant patients into the IT platform. 3. Implement the multidrug web platform to predict the clinical evolution of liver transplant patients.
Official title: Development of a Pharmaco-proteomic Platform to Evaluate Potential Drug Interactions and Their Clinical Impact in Liver Transplant Patients Undergoing Multidrug Treatment
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
48
Start Date
2023-06-01
Completion Date
2025-05-05
Last Updated
2024-11-12
Healthy Volunteers
No
Interventions
Multi-drug interaction
The clinical impact associated with the use of multiple drugs in liver transplant patients during their stay in ICU will be evaluated.
Locations (3)
Universidad de Valparaíso
Valparaíso, Región de Valparaíso, Chile
Hospital ClínicoUC-Christus
Santiago, Santiago Metropolitan, Chile
Pontificia Universidad Católica de Chile
Santiago, Santiago Metropolitan, Chile