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RECRUITING
NCT06683261

Real-life Evaluation of the Efficacy of Biologicals in Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)

Sponsor: Universitaire Ziekenhuizen KU Leuven

View on ClinicalTrials.gov

Summary

The goal of this observational study is to learn more about the real-world efficacy of biologics in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP). All patients who are 18 years or older, who have CRSwNP and are eligible for reimbursement of a biological for the indication of CRSwNP can be included. The main question is the efficacy of biologics in real life after 24 weeks. The main focus are patient reported outcomes measured via several questionnaires and the nasal polyp score, scored with nasal endoscopy.

Official title: Real-life Evaluation of the Efficacy of Biologicals in CRSwNP

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

300

Start Date

2022-09-23

Completion Date

2026-12

Last Updated

2024-11-12

Healthy Volunteers

No

Interventions

BIOLOGICAL

Omalizumab

biological prescribed as add-on treatment as part of the standard of care

BIOLOGICAL

Dupilumab

biological prescribed as add-on treatment as part of the standard of care

BIOLOGICAL

Mepolizumab 100 mg

biological prescribed as add-on treatment as part of the standard of care

Locations (8)

Onze Lieve Vrouw hospital Aalst

Aalst, Belgium

General hospital Sint-Jan Bruges

Bruges, Belgium

University hospital Saint-Luc

Brussels, Belgium

University hospital of Antwerp

Edegem, Belgium

Hospital Zuid-Oost Limburg

Genk, Belgium

University Hospital Brussels

Jette, Belgium

University hospitals Leuven

Leuven, Belgium

CHU de Liège

Liège, Belgium