Clinical Research Directory

Inclusion Criteria: 1. Aged 18-45 years (including 18 and 45), no gender restriction; 2. Meets the diagnostic criteria for depressive disorders according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-Ⅴ); 3. Outpatients or inpatients; Hamilton Depression Rating Scale 17-item (HAMD-17) score ≥ 17; Clinical Global Impressions-Severity (CGI-S) score = 4; 4. Maintenance treatment with antidepressants in the class of Selective Serotonin Reuptake Inhibitors (SSRIs) for at least 4 weeks, or no previous treatment with antidepressants, and can be combined with Lorazepam 0.5mg/dose and Zolpidem Tartrate 5-10mg/n during insomnia and anxiety attacks; 5. Written informed consent obtained from the patient. Exclusion Criteria: 1. Diagnosed with other mental disorders, including schizophrenia, bipolar disorder, alcohol or substance abuse/dependence, eating disorders, etc.; 2. Individuals with intellectual disabilities or who are unable to cooperate for other reasons, or those lacking or having incomplete civil capacity during the onset of illness; 3. Suffering from neurological or organic brain diseases (such as stroke, cerebral hemorrhage, brain tumors, Parkinson's disease, epilepsy, etc.) and a history of severe traumatic brain injury; 4. Currently undergoing systematic psychological therapy; 5. Individuals who had been treated with convulsion-free electroconvulsive therapy within the last month; 6. Pregnant women or individuals with contraindications to MRI examinations; 7. Individuals who don't know how to use or don't have a smartphone; 8. Individuals with severe suicidal tendencies or at risk of harming others.