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Physical Activity to Prevent and Treat Hyperglycemia From a Mistimed Bolus Insulin Dose
Sponsor: Jane Yardley
Summary
People living with type 1 diabetes (PwT1D) are recommended to administer insulin 10-15 minutes before meal consumption (pre-bolus), to account for the delay in the glucose lowering action associated with subcutaneously administered insulin. Due to the demands of day-to-day life, pre-bolusing is not always possible or may be forgotten. With continuous glucose monitors (CGMs), PwT1D may be alerted to this missed insulin dose by a CGM alert, including rapidly rising glucose (change \>2.5mmol/L/15min) or hyperglycemia (\>10.0 mmol/L), and deliver a mistimed (post-prandial) dose in response to CGM alert. This study was designed to determine the effect of combining a post-prandial/mistimed insulin dose with 15 minutes of brisk walking. It is expected that walking will help to minimize or prevent hyperglycemia after a mistimed bolus insulin dose, as well as blunt the rise in glucose following a mistimed insulin dose.
Official title: Physical Activity to Prevent and Treat Hyperglycemia From a Mistimed Bolus Insulin Dose: The MISSED DOSE Study
Key Details
Gender
All
Age Range
18 Years - 24 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-03-17
Completion Date
2026-09-30
Last Updated
2026-03-12
Healthy Volunteers
No
Conditions
Interventions
Control (CON)
Standardized meal with insulin administered 15 minutes before eating
Missed Dose (MISS)
Standardized meal with insulin administered post-prandially when alerted to rapidly rising glucose (increase of 0.2 mmol/L/min) or hyperglycemia (\> 10.0 mmol/L) by CGM
Missed Dose + 15min walk (MISS+EX)
Standardized meal with insulin administered post-prandially when alerted to rapidly rising glucose (increase of 0.2 mmol/L/min) or hyperglycemia (\> 10.0 mmol/L) by CGM with a 15-minute walk performed immediately after insulin administration
Locations (1)
Institut de recherches cliniques de Montréal
Montreal, Quebec, Canada