Clinical Research Directory

Inclusion Criteria: * Is at least 18 years of age and has full legal capacity to volunteer. * Has read and signed an information consent form. * Is willing and able to follow instructions and maintain the appointment schedule. * Has dry eye disease as per the TFOS DEWS II definition with a clear moderate to severe evaporative Dry Eye: * OSDI ≥ 13 * And TBUT \< 10 seconds * And \>5 spots of corneal fluorescein staining OR \> 9 conjunctival spots * Meibomian Gland score of 1 or higher using NEI grading criteria. Exclusion Criteria: * Is participating in any concurrent clinical or research study. * Is wears contact lenses. * Is using any systemic medications that could impact the aqueous tear layer, including antihistamines, vitamin A analogues, phenothiazines, anti-anxiety drugs, antidepressants, and other medications with anticholinergic activity. * Has undergone eye surgery involving the cornea or conjunctiva. * Aqueous deficient DED patients. * Is currently or has used any of the study drops in the last 3 months. * Has any known allergy or intolerance to any of the study drops. * Has any known active ocular disease such as allergies and/or infection or any ocular disease that in the opinion of the investigator may affect a study outcome variable * Has a systemic condition that in the opinion of the investigator may affect a study outcome variable (e.g. uncontrolled autoimmune disease or uncontrolled immunodeficiency disease). * Has known sensitivity to sodium fluorescein. * Is pregnant, lactating or planning a pregnancy at the time of enrolment? * Unwilling to stop using their habitual artificial tears for the study. * Has been fitted with punctal plugs within 30 days before the study screening visit. * Contact lens users can still qualify for the study, however, participants should restrain their contact lens use to a very minimum during the study duration.