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Non-Steroidal Anti-Inflammatory Drugs in Acute Myocarditis
Sponsor: Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Summary
Prospective, randomized, multicenter, open-label clinical trial to evaluate the safety and efficacy of a 3-week ibuprofen tapering regimen compared to conventional analgesic treatment (acetaminophen) in patients with acute myocarditis and left ventricular ejection fraction ≥50%. The objective is to assess the reduction in late gadolinium enhancement on cardiac magnetic resonance imaging at 6-month follow-up.
Official title: Non-Steroidal Anti-Inflammatory Drugs Versus Conventional Treatment in Acute Myocarditis (INFLAMA Trial)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2025-04-28
Completion Date
2027-10
Last Updated
2026-02-13
Healthy Volunteers
No
Conditions
Interventions
ibuprofen
Ibuprofen tapering schedule during 3 weeks. First week: Ibuprofen 600 mg every 8 hours. Second week: Ibuprofen 600 mg every 12 hours. Third week: Ibuprofen 600 mg every 24 hours.
Locations (1)
Hospital Universitario Puerta de Hierro-Majadahonda
Majadahonda, Madrid, Spain