Clinical Research Directory

Inclusion Criteria: PIPO Population: 1. Minor or adult patient ≥ 4 years of age 2. Patient with PIPO before age 18 3. Male or female 4. Patient with PIPO meeting at least 2 of the ESPGHAN criteria (Thapar et al 2018) and carrying the R178, R257, R40 or A136 mutation of the ACTG2 gene. 5. Patient whose assent has been obtained and whose legal guardians have given their written informed consent 6. Patient affiliated to the French Social Security system or benefiting from an equivalent plan WT population: \- iPS cell lines MS573 or WT8288 or 202CT or SD378M, from the Nantes University Hospital biological collection and generated from samples from control patients without POIC who have consented to donate their samples. Exclusion Criteria: PIPO population : 1. Patients with a history of radiotherapy treatment 2. Patient with lymphocyte lineage damage