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Effects of Exercise Training and Genetic Factors in Hypertensive Patients with Obstructive Sleep Apnea Sleep
Sponsor: University of Sao Paulo General Hospital
Summary
The objective is to investigate the effects of exercise training in hypertensive individuals with obstructive sleep apnea (OSA) in neurovascular control taking into account genetic factors. Seventy-two hypertensive patients with OSA \>15 events/hour of sleep revealed by nocturnal polysomnography will be randomized into a control or physical training group. All will be evaluated for the T786 genotypes of the eNOS gene gene. The study will investigate the effect of the exercise program on vascular control in different alleles of the T786 genotypes of the eNOS gene.
Official title: Effects of Exercise Training on Neurovascular Control, Endothelial Function, Cognitive Functioning and Genetic Factors in Hypertensive Patients with Obstructive Sleep Apnea Sleep
Key Details
Gender
All
Age Range
45 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
72
Start Date
2024-02-26
Completion Date
2028-02-25
Last Updated
2024-11-14
Healthy Volunteers
No
Conditions
Interventions
Exercise training
Includes aerobic exercise, strength training, streching
Locations (1)
Linda Massako Ueno Pardi
São Paulo, São Paulo, Brazil