Clinical Research Directory

Inclusion Criteria: * Patients aged 18-65 who will undergo laparotomic lower and upper gastrointestinal system surgery Exclusion Criteria: * American society of anesthesia of 4-5 patients * Patients without voluntary consent * Patients with previous surgery or vertebrobasilar insufficiency * Patients with Carotis stenosis * Patients with a visual analog scale above 4 in the postoperative recovery unit * Patients whose cerebral oxygenation decreased by 15% from the beginning in cerebral oximetry monitoring during the perioperative period * Patients with bleeding that disrupts hemodynamics during follow-up and bleeding greater than 20% of body volume * Patients with postoperative intensive care unit follow-up * Patients with a decrease of more than 20% from the baseline systolic value (based on ward monitoring) during follow-up * Patients with intraoperative ventilation failure, patients with hypercarbia, hypocarbia * Patients whose Patient State Index value falls below 25, which is sufficient for the depth of anesthesia, during anesthesia induction or maintenance. * Patients with known neurological, psychiatric, unstable cardiovascular, renal or hepatic system disease * Patients with Uncontrolled Hypertension * Patients with greater than 1st degree heart block * Patients allergic to α2 adrenergic receptor agonist * Patients who cannot speak and do not know Turkish * Alcohol and substance addicted patients * Patients who have used opioids in the last 24 hours * Patients who developed sepsis during postoperative follow-up * Patients with a history of recurrent surgery