Clinical Research Directory

Inclusion Criteria: * Patients with benign prostatic hyperplasia aged 55 to 75 years old; * The patient's prostate volume is greater than 40mL; * There is urinary obstruction, with an International Prostate Symptom Score (IPSS) greater than or equal to 8 points, and a maximum urinary flow rate of less than 15ml/s (urinary flow rate is not measured in patients with indwelling catheters). Exclusion Criteria: * Urinary disorders caused by neurogenic diseases; * Acute urinary tract infections have not been effectively controlled; * There are factors of lower urinary tract obstruction other than BPH, such as urethral stricture; * History of radiation therapy or surgery in the lower urinary tract or pelvic cavity; * Have ever suffered from tumor of urinary system, or suspected of suffering from tumor of urinary system (such as bladder cancer cancer, prostate cancer); * Current or past liver function abnormalities (exceeding the test reference value limit); * Abnormal renal function (exceeding the test reference value limit); * Currently taking warfarin; * Allergic to tranilast or drug preparations; * Suffering from other major diseases (malignant tumors, autoimmune diseases, angina pectoris, heart failure, severe respiratory and digestive diseases, etc.), and not yet clinically cured; * Other researchers believe that patients who are not suitable to participate in this trial.