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RECRUITING
NCT06690164
PHASE4

Study on the Effect of Atorvastatin Co-administered With Omeprazole on Statin Lactone

Sponsor: National University Hospital, Singapore

View on ClinicalTrials.gov

Summary

This is a 2-arm, prospective, randomized, parallel-group, open-label, longitudinal study that lasts 30 days for each study participant. This study aims to investigate the effect of co-administration of Omeprazole with Atorvastatin versus Atorvastatin monotherapy on atorvastatin lactone level. Primary endpoint: Higher statin lactone level in intervention arm after 30 days. Secondary endpoints: Higher hs-CRP in intervention arm Lipid panel Incidence of adverse drug side effects (e.g. muscle-related or elevated LFTs

Official title: Study on the Effect of Atorvastatin Co-administered With Omeprazole on Statin Lactone (SEACOL)

Key Details

Gender

All

Age Range

21 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

78

Start Date

2025-06-12

Completion Date

2026-06

Last Updated

2025-07-02

Healthy Volunteers

Yes

Conditions

Interventions

DRUG

Atorvastatin 40mg Tablet

once a day for 30 days

DRUG

Omeprazole 20mg Capsule

once a day for 30 days

Locations (1)

National University of Singapore (NUS) MD6 Level 8

Singapore, Singapore