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Study on the Effect of Atorvastatin Co-administered With Omeprazole on Statin Lactone
Sponsor: National University Hospital, Singapore
Summary
This is a 2-arm, prospective, randomized, parallel-group, open-label, longitudinal study that lasts 30 days for each study participant. This study aims to investigate the effect of co-administration of Omeprazole with Atorvastatin versus Atorvastatin monotherapy on atorvastatin lactone level. Primary endpoint: Higher statin lactone level in intervention arm after 30 days. Secondary endpoints: Higher hs-CRP in intervention arm Lipid panel Incidence of adverse drug side effects (e.g. muscle-related or elevated LFTs
Official title: Study on the Effect of Atorvastatin Co-administered With Omeprazole on Statin Lactone (SEACOL)
Key Details
Gender
All
Age Range
21 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
78
Start Date
2025-06-12
Completion Date
2026-06
Last Updated
2025-07-02
Healthy Volunteers
Yes
Conditions
Interventions
Atorvastatin 40mg Tablet
once a day for 30 days
Omeprazole 20mg Capsule
once a day for 30 days
Locations (1)
National University of Singapore (NUS) MD6 Level 8
Singapore, Singapore