Clinical Research Directory

Inclusion Criteria: * 1\. Subject capable of understanding written information ,willing to participate in, and provide a written informed consent; * 2.Male or female subjects must be at least 18 years old when signing the informed consent; * 3.The subjects must undergo regular maintenance hemodialysis three times a week for at least three months； * 4.Dialysate calcium concentration≥1.25 mmol/L (2.5 mEq/L); * 5.Diagnosed of Secondary Hyperparathyroidism (SHPT), with averaged iPTH ≥400 pg/ml14 days prior to screening; * 6.Receiving active vitamin D sterols must have had no more than a maximum dose change of 50% within the 1 month prior to screening, remain stable; * 7.Subject receiving calcium supplements, or phosphate binders must have had no more than a maximum dose change of 50% within the 2 weeks prior to screening, remain stable; Exclusion Criteria: * 1.The subjects underwent parathyroidectomy within 6 months prior to screening, or plan to undergo parathyroidectomy or ablation or radiation during the study; * 2.Gastrointestinal bleeding or peptic ulcer medical history within 6 months prior to screening; * 3.The body mass index of the subjects was less than 18kg/m2 or greater than 35 kg/m2; * 4.Subjects with severe uncontrolled hypertension, defined as systolic blood pressure\>180 mmHg and/or diastolic blood pressure\>110 mmHg(Except for transient blood pressure abnormalities seen during dialysis), despite optimal drug treatment prior to enrollment; * 5.History of epileptic seizures or ongoing epilepsy related treatment within 1 year prior to screening; * 6.Subjects with a history of malignant tumors within the past 5 years prior to screening; * 7.Subjects are allergic or intolerant to any component of the investigational drug or Etelcalcetide