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Prophylactic Amnioinfusion for Prevention of Postpartum Hemorrhage
Sponsor: The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to decrease the likelihood of composite postpartum hemorrhage (PPH) morbidity, which consists of i) Estimated or quantified blood loss of 1,500 mL or more, ii) transfusion of any blood products or iii) hysterectomy
Official title: Prophylactic Amnioinfusion for Prevention of Postpartum Hemorrhage: A Randomized Clinical Trial (PURPOSE)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
700
Start Date
2024-11-11
Completion Date
2027-05-01
Last Updated
2024-11-18
Healthy Volunteers
No
Conditions
Interventions
Saline delivered using an intrauterine pressure catheter (IUPC)
An intrauterine pressure catheter (IUPC) will be placed in participants after membrane rupture, or at 4 cm if membranes previously ruptured. A 300cc bolus of normal saline will be administered. A continuous rate of 100 cc/hr of normal saline will continue until delivery to prevent Postpartum Hemorrhage. If the IUPC is dislodged, it will be replaced by a trained clinician.
Locations (1)
The University of Texas Health Science Center at Houston
Houston, Texas, United States