Clinical Research Directory

Inclusion Criteria 1. Age ≥18; and 2. Requiring norepinephrine at a dose of 0.05-0.25 mcg/kg/min mcg/kg/minute despite adequate fluid resuscitation; and 3. Receiving intravenous antibiotics or clinician's intention to administer antibiotics at the time of enrollment; and 4. Can provide written informed consent (or legally authorized representative). Exclusion Criteria 1. Acute coronary syndrome; 2. Cardiogenic shock; 3. Patients with a history of mesenteric ischemia; 4. Patients with a history of having an aortic dissection or abdominal aortic aneurysm; 5. Patients with an expected lifespan of \<12 hours; 6. Patients with hemorrhagic shock (e.g., actively receiving transfusion of packed red blood cells); 7. Active administration of two vasoactive agents before enrollment; and 8. Pre-existing thromboembolic disease or inability to tolerate pharmacologic VTE prophylaxis.