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A Danish Pragmatic Randomized Trial of Nutritional Supplements in Heart Failure
Sponsor: Tor Biering-Sørensen
Summary
Heart failure is a common and serious condition. Despite rapid advancements in heart failure treatment, the prognosis remains severe. Smaller studies have shown that two simple, safe, and relatively inexpensive nutritional supplements-coenzyme Q10 and selenium-may reduce the risk of complications associated with heart failure. The DANUTRIO-HF trial will investigate whether these supplements can make a difference for individuals with heart failure. The study will assign approximately 4,044 patients from across Denmark to either coenzyme Q10 (100 mg twice daily) or a corresponding placebo, as well as selenium (100 μg twice daily) or its corresponding placebo, and follow how many of them end up being hospitalized for heart failure or dying from heart problems over an estimated two to three-year period.
Official title: A Danish Pragmatic Randomized Trial of Nutritional Supplements in Heart Failure (DANUTRIO-HF: Q10, DANUTRIO-HF: Selenium)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
4044
Start Date
2025-09-30
Completion Date
2029-06-01
Last Updated
2025-10-03
Healthy Volunteers
No
Conditions
Interventions
Coenzyme Q10 100 Milligrams Oral Capsule
100 mg capsules given twice daily, per oral use.
Selenium 100 Micrograms Oral Tablets
100 μg tablets given twice daily, per oral use.
Locations (1)
Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte
Hellerup, Denmark