Clinical Research Directory

Inclusion Criteria: * Male or female (balanced sex ratio or at least 40% male to 60% female) in complete autonomy at home. * 55 to 75 years old, including the limits * 20 ≤ BMI ≤35 kg/m2 * Available to carry out the entire protocol, including self-sampling (not sensitive to the sight of one's own blood for example) and agreeing to stop taking food supplements during the study. * Having a scale available: at home, pharmacy, family, etc. * Having internet access and a device with a screen and camera (PC, tablet, smartphone, etc.) at home or able to go to a project partner (CCAS, Point France Service, Community, Association, etc.) that can provide this access * Subject agreeing to give written consent (by phone or videoconferencing), and registration in the national file of volunteers who participate in research * Person declaring to be subject to a social security scheme. Exclusion Criteria: * Weight loss ≥ 5% in 1 month or ≥ 10% in 6 months or ≥ 10% compared to usual weight * Treated diabetes * Sub-acute pathology (flu, gastroenteritis, bacterial infection, etc.) or trauma (fracture, surgical intervention, etc.) in the 30 days prior to inclusion. * Hepatocellular insufficiency, * Heart failure with decompensation, * Renal insufficiency (clearance \<30 ml/min) * Chronic anti-inflammatory treatment, long-term corticosteroid therapy \> 1 month, infiltration * Progressive pathology at the time of inclusion (cancer, etc.) * Gastrointestinal pathology deemed incompatible with the protocol * Unstable thyroid diseases * Recent change in eating habits in the last 30 days (weight loss diet, veganism, intermittent fasting, ketogenic diet, etc.) * Intense physical activity (activity causing shortness of breath and sweating) \> 10 hours per week * Person in a period of exclusion from the National File of Healthy Volunteers * Subject under guardianship, curator-ship, deprived of liberty or under judicial protection