Clinical Research Directory

Inclusion Criteria: 1. Diagnosis as acute ischemic stroke according to the Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2018; 2. First clinical onset or previous presence of cerebral infarction without severe sequelae（Premorbid mRS ≤2） 3. Age≥18 years, male or female; 4. 3≤Baseline NIHSS≤25; 5. Written informed consent obtained from the patient or legally responsible person. Exclusion Criteria: 1. Cerebral hemorrhage and the acute phase of other hemorrhagic diseases； 2. Previously allergic or intolerant to injectable HUK； 3. Used ACEI drugs prior to medication and less than 5 half-lives of the drug (according to the specific drug instructions) or received ACEI drugs during the study period; 4. Stent surgery after the AIS onset or planned interventional therapy; 5. Pregnancy, lactation or planned pregnancy； 6. Life expectancy of less than 3months or inability to complete the study for other reasons； 7. Unwilling to be followed up or poor compliance； 8. Current participation in other clinical research; 9. Other causes of AIS (such as dissection, vasculitis, pre-thrombotic lesions, drug abuse).