Clinical Research Directory

Inclusion Criteria: For Neoadjuvant therapy: * T2-T4aN0M0 bladder patients For Adjuvant therapy: * Postoperative pathological stage T3-T4 and/or lymph node metastasis were positive. Exclusion Criteria: * The researchers evaluated the patients who could not tolerate radical surgery; * Previously received systemic chemotherapy or immunotherapy; * There are active autoimmune diseases requiring systemic treatment or other diseases requiring long-term use of a large number of hormones and other immunosuppressants; * Have had major surgery or major trauma within 28 days before joining the group; * Vaccinated with live vaccine within 28 days before joining the group.