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RECRUITING
NCT06697197
PHASE1/PHASE2

A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

Sponsor: Bristol-Myers Squibb

View on ClinicalTrials.gov

Summary

The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.

Official title: A Phase 1/2 Study of BMS-986482 as Monotherapy or Combination Therapy in Participants With Advanced Solid Tumors

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

413

Start Date

2025-02-17

Completion Date

2029-01-05

Last Updated

2026-02-03

Healthy Volunteers

No

Interventions

DRUG

BMS-986482

Specified dose on specified days

DRUG

Nivolumab and rHuPH20

Specified dose on specified days

DRUG

Nivolumab/relatlimab/rHuPH20

Specified dose on specified days

DRUG

Bevacizumab

Specified dose on specified days

Locations (21)

University of California, Irvine (UCI) Health - UC Irvine Medical Center

Irvine, California, United States

The Angeles Clinic and Research Institute - West Los Angeles Office

Los Angeles, California, United States

Local Institution - 0008

Aurora, Colorado, United States

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, United States

Northwell Health/ RJ Zuckerberg Cancer Center

Lake Success, New York, United States

Levine Cancer Institute

Charlotte, North Carolina, United States

Fred Hutchinson Cancer Center

Seattle, Washington, United States

UZ Gent

Ghent, Oost-Vlaanderen, Belgium

Rigshospitalet

Copenhagen, Capital Region, Denmark

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

Marseille, Bouches-du-Rhône, France

Gustave Roussy

Villejuif, Paris, France

General Hospital of Athens "Laiko"

Athens, Attikí, Greece

Papageorgiou General Hospital of Thessaloniki

Thessaloniki, Thessaloníki, Greece

Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, Lombardy, Italy

Istituto Clinico Humanitas

Rozzano, Milano, Italy

Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)

Amsterdam, North Holland, Netherlands

Erasmus Medisch Centrum

Rotterdam, Netherlands

Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [Barcelona], Spain

Clinica Universidad de Navarra

Pamplona, Navarre, Spain

Hospital Universitario HM Sanchinarro

Madrid, Spain

Karolinska Universitetssjukhuset Solna

Solna, Stockholms Län [se-01], Sweden