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Efficacy of Statins Among Major Depressive Disorder
Sponsor: Ain Shams University
Summary
The goal of this clinical trial is to learn if drug Rosuvastatin 10 mg works to treat MDD in adults. It will also learn about the safety of Rosuvastatin 10 mg .The main questions it aims to answer are: Does Rusovastatin lower the score of The Montgomery Asberg Depression Rating Scale (MADRS) among adult participants with Major Depression Disorder ( MDD )? What medical problems do participants have when taking drug ABC? Participants will: Take Rosuvastatin 10 mg every day for 3 months Visit the clinic once every 4 weeks for checkups and tests Report any side effects for Rosuvastatin 10 mg and reassess the severity of depression using The Montgomery Asberg Depression Rating Scale (MADRS)
Official title: The Efficacy of Statins in Management of Major Depression Disorder (MDD) Among Adult Patients Attending the Outpatient Clinics of El Demerdash Hospital.
Key Details
Gender
All
Age Range
20 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
145
Start Date
2022-10-01
Completion Date
2025-12-31
Last Updated
2025-08-17
Healthy Volunteers
Yes
Conditions
Interventions
Rosuvastatin 10 mg tablet.
The dose of rosuvastatin was derived from literature describing the doses at which the agents' targeted actions are effective and safe. The 10- mg rosuvastatin dose reflects the lowest prescribed therapeutic dose A serum cholesterol level will be drawn from the whole participants and sent to the central laboratories of El-Demerdash hospital at baseline and at week 12. At each visit, participants will be requested to return all unused investigational products. Adherence to medication will be assessed by a pill count.
Sertraline Pill
Both control and intervention group will receive the sertraline as a standard therapy
Locations (1)
El demerdash hospital
Cairo, Al Abbasia, Egypt