Clinical Research Directory

Inclusion Criteria: * 1\) The history of acute myocardial infarction exceeds 3 months; * 2\) Symptoms and signs of heart failure have been stable for more than one month; * 3\) 18 years old or more; * 4\) NYHA cardiac function classified as grade II\~IV; * 5\) LVEF≤40%； * 6\) NT-proBNP≥450pg/ml； * 7\) All subjects or their guardians must sign the subject consent before entering the trial. Exclusion Criteria: * 1\) Patients with the following diseases: nonischemic cardiomyopathy; valvular heart disease; congenital heart disease; obstruction of left ventricular outflow tract; severe decompensated heart failure; active myocarditis or pericardial disease; end-stage liver and kidney diseases; malignant tumor; * 2\) Planned to undergo cardiac surgery within 12 months; * 3\) Mechanical complications of myocardial infarction; * 4\) Pregnant or nursing, or having the intention to give birth within one year; * 5\) Patients who participated in clinical research of other drugs within 3 months before being selected; * 6\) Patients with poor sound transmission windows are examined by transthoracic ultrasound.