Clinical Research Directory

Inclusion Criteria: 1. Suffer from schizophrenia (as assessed in agreement with ICD-11 criteria). 2. Age between ≥18 and \<65 years. 3. Currently receiving inpatient or outpatient psychiatric treatment. 4. Experienced any of the following suboptimal treatment conditions while receiving antipsychotic medication within the therapeutic dosage range: 1. Standard antipsychotic treatment for more than 2 weeks with the occurrence of drug-induced adverse effects requiring dose adjustment or a switch of medication. 2. Antipsychotic treatment within the therapeutic dosage range for more than 4 weeks, with the presence of at least two items of the Positive and Negative Syndrome Scale (PANSS) (P1, P2, P3, N1, N4, N6, G5, and G9) score ≥4, or a total PANSS score \>70, or a CGI-S score ≥4. 3. Other situations where a change in medication is deemed necessary, as assessed by senior clinical physicians. 5. Understand the study requirements and provide written informed consent to participate; a signed and dated informed consent form (ICF) will be obtained from each patient before participation in the study. Exclusion Criteria: 1. Presence of organic brain disease or a severe and/or unstable physical condition. 2. Substance abuse or dependence within the past 6 months or currently. 3. Presence of elevated levels of agitation, impulsivity, or risk of self-injury or suicide. 4. Pregnant or breastfeeding women. 5. The presence of any other conditions that may render the individual ineligible for participation in this clinical trial.