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Targeting Cervical Epidural Spinal Cord Stimulation for Functional Recovery
Sponsor: Columbia University
Summary
The proposed study seeks to understand how the cervical spinal cord should be stimulated after injury through short-term physiology experiments that will inform a preclinical efficacy trial. The purpose of this study is to determine which cervical levels epidural electrical stimulation (EES) should target to recruit arm and hand muscles effectively and selectively in spinal cord injury (SCI).
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2024-12-06
Completion Date
2026-06-30
Last Updated
2025-11-24
Healthy Volunteers
No
Interventions
Intraoperative stimulation of the cervical spinal cord
The surgeon will place spinal cord electrodes on the epidural surface, with stimulation sites identified using preoperative MRI. Recruitment curves will be generated by systematically increasing the stimulation intensity across various parameter combinations, including frequency, pulse count, pulse shape, and electrode-specific properties such as size, separation, and arrangement.
Locations (2)
Columbia University Irving Medical Center
New York, New York, United States
The Daniel and Jane Och Spine Hospital at NewYork-Presbyterian/Allen
New York, New York, United States