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Nitrous Oxide Neuroimaging
Sponsor: Keith M Vogt
Summary
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
Official title: Functional MRI of Nitrous Oxide Inhalation in Volunteer Subjects
Key Details
Gender
All
Age Range
18 Years - 59 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2025-01-13
Completion Date
2026-06-01
Last Updated
2025-12-18
Healthy Volunteers
Yes
Conditions
Interventions
Nitrous oxide
After a no-drug control period, subjects will inhale nitrous oxide, administered via a breathing circuit and face mask, until a steady-state target end-tidal expired concentration is reached. During the drug condition, subjects will receive low-dose nitrous oxide (% corresponding to Minimum Alveolar Concentration).
Peripheral Nerve Stimulation
Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with a fixed number of the experimental cues, in a pattern that appears random to participants.
Locations (1)
University of Pittsburgh
Pittsburgh, Pennsylvania, United States