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Anticholinergics for Cervical Edema in Labor
Sponsor: The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to is to determine the clinical effectiveness of a single dose of intravenous (IV) medication for the prevention of labor arrest and cesarean delivery in primiparous women undergoing trial of labor.
Official title: Anticholinergics for Cervical Edema in Labor (ACCEL)
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2025-03-25
Completion Date
2027-04-09
Last Updated
2026-05-06
Healthy Volunteers
No
Conditions
Interventions
Treatment with Diphenhydramine
Diphenhydramine 50mg IV will be administered within 1 hour of the cervical exam which diagnosed prolonged active phase of labor
Usual Care
Participants will receive cervical exams every 2 hours in active labor, placement of intrauterine pressure catheter, up titration of Pitocin if contractions are inadequate, maternal repositioning, and use of adjunct devices such as a peanut ball.
Locations (1)
The University of Texas Health Science Center at Houston
Houston, Texas, United States