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Early Screening for Gestational Diabetes Mellitus in a Low Risk Population
Sponsor: National University Hospital, Singapore
Summary
This new feasibility pilot study aims to refine the design and protocols for a larger trial that will investigate the potential benefits of early oral glucose tolerance test (OGTT) screening in a population traditionally defined as low-risk for development of gestational diabetes. The study will evaluate its potential effectiveness in reducing the risks of neonatal morbidity/mortality and obstetric complications. Additionally, a machine learning algorithm to predict gestational diabetes mellitus (GDM) risk based on routinely obtained clinical information at pregnancy booking, and minimally invasive methods, such as continuous glucose monitoring (CGM) and gingival crevicular fluid (GCF) sampling, are being explored to predict the risk of hyperglycaemia. This study aims to investigate the utility of early pregnancy screening to enable timely detection and management of early gestational diabetes development in a low-risk population, ultimately promoting better health outcomes for mothers and their babies.
Key Details
Gender
FEMALE
Age Range
21 Years - 39 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2024-12-01
Completion Date
2026-11-30
Last Updated
2024-11-25
Healthy Volunteers
Yes
Interventions
Early OGTT Results Revealed
Early pregnancy screening with a three-time point (fasting, 1h, 2h) 75g oral glucose tolerance test before 16 weeks' gestation with plasma glucose results revealed to the patient and clinician for appropriate management of any diabetes (gestational and type 2, if diagnosed) from early pregnancy onwards.
Locations (1)
National University Hospital
Singapore, Singapore