Clinical Research Directory

Inclusion Criteria: 1. Aged 18-50 years (including 18 years and 50 years); 2. Best-corrected visual acuity worse than 20/30 but no worse than 20/200 in the amblyopic eye, interocular difference of 2 or more lines, with the better eye within the normal range; 3. Patients with deprivation amblyopia should have relieved the deprivation factors such as opacification of the ocular media (e.g. cataract, nonclearing vitreous opacity, corneal opacities) or other occlusion of the visual axis (e.g. blepharoptosis). 4. Normal binocular alignment including strabismic amblyopia with orthotropia after optical refractive correction or surgical correction, or intermittent exotropia within a range of -15 to 0 prism diopters measured by the prism cover test. 5. Patients should have been applyng optical refractive correction for more than 3 months before enrollment. Exclusion Criteria: 1. Organic eye diseases preventing the establishment of good vision (e.g. ptosis, media opacity, nystagmus, paracentral fixation, acute inflammation like keratitis, optic nerve diseases like glaucoma, retinal diseases); 2. Lesions of the brain preventing the establishment of good vision (e.g. cortical visual impairment); 3. A history of ocular surgery (except strabismus surgery) affecting vision (e.g. retinal detachment repair); 4. A history of ocular trauma affecting vision; 5. Receiving amblyopia therapy (except wearing refractive correction glasses) within 2 weeks before enrollment; 6. History of epilepsy or mental illness, or cognitive defects; 7. Currently taking medications or needing to take medications during the study period that may affect vision; 8. Contraindications to magnetic resonance imaging such as implantable electronic device, metal implants (e.g. metal dentures, craniofacial titanium plates), claustrophobia and pregnancy.