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No Axillary Surgical Treatment in Clinically Lymph Node Negative Patients on Ultrasonography After Neoadjuvant Chemotherapy
Sponsor: Seoul National University Hospital
Summary
NEO-NAUTILUS is a prospective, multicenter, randomized phase III clinical trial to evaluate whether omitting axillary lymph node surgery (ALND or SLNB) in clinically lymph node-negative breast cancer patients after neoadjuvant chemotherapy is non-inferior to performing SLNB in terms of 5-year disease-free survival.
Official title: No Axillary Surgical Treatment in Clinically Lymph Node Negative Patients on Ultrasonography After Neoadjuvant Chemotherapy: A Prospective, Phase III Clinical Trial
Key Details
Gender
FEMALE
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
464
Start Date
2025-06-04
Completion Date
2034-12-31
Last Updated
2026-01-28
Healthy Volunteers
No
Interventions
No axillary surgery
BCS only. Ommission of axillary surgery. No axillary surgery after neoadjuvant chemotherapy.
Axillary surgery
BCS with SLNB(+/-ALND)
Locations (1)
Seoul National University Hopsital
Seoul, South Korea