Clinical Research Directory

Inclusion Criteria: * Age ≥ 25 years to ≤ 75 years，with sexual life history * Meet the diagnostic criteria for high-risk human papillomavirus (HR-HPV) persistent infection * After surgery or physical therapy for high-grade squamous intraepithelial lesions (HSIL) of the cervix or high-grade squamous intraepithelial lesions (VaINIII) of the vagina, or radical surgery for cervical/vaginal cancer or radical chemoradiotherapy, the examination remained positive for HR-HPV ≥6 months after the end of treatment, with the same type or multiple types as before treatment, and no progression or recurrence of the disease. * No local or systemic therapy has been administered to patients in the last 3 months * Patients were informed of the study protocol, agreed to cooperate with the treatment, and signed informed consent. Exclusion Criteria: * Only low-risk HPV infection * Colposcopy for high-grade intraepithelial lesions or cancer of the cervix, vagina, vulva, who have not received or are receiving treatment * Immunocompromised or immunosuppressant * Pregnant and lactating women * Patients with other malignant tumors not controlled, serious heart, lung, liver, renal insufficiency and coagulation dysfunction * People with communication or cognitive impairment * Patients have contraindications to oral administration of traditional Chinese medicine preparations * In the same period, other anti-HPV measures were used to treat, which affected the efficacy judgment