Clinical Research Directory

Inclusion Criteria: Fetuses with congenital heart disease : * Pregnant women aged 18 and more * Single foetal pregnancy in which the foetus has a complex non-syndromic congenital heart defect, with no identified chromosomal abnormality, gene syndrome or infection. * Patient for whom the indication for amniocentesis has been accepted by the CPDPN and accepted by the couple/patient * Gestational age between 20 and 28 weeks' gestation. * Person affiliated to or benefiting from a social security scheme. * Free, informed and express consent (confirmed in writing) (at the latest on the day of inclusion and before any examination required by the research). Control Population for RNAseq and MéthlySeq * Pregnant women aged 18 and more * Patient in whom the indication for amniocentesis has been retained by the CPDPN and accepted by the couple/patient, for a non-malformative ultrasound anomaly (hyperechoic bowel, idiopathic hydramnios, increased risk of trisomy 21, agenesis of the OPN, suspected toxoplasmosis/CMV seroconversion), with no chromosomal anomaly, gene syndrome or infection identified. * Gestational age between 20 and 28 weeks' gestation. * Person affiliated to or benefiting from a social security scheme. * Free, informed and express consent (confirmed in writing) (at the latest on the day of inclusion and before any examination required by the research). Exclusion Criteria: For both populations (cases and controls) : * Female minors, * Patients not affiliated to the social security system, * Patients who do not understand French, * Patients under guardianship * Multiple pregnancies, or where the foetus has associated malformations