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The Expression of CD24 "do-not-eat-me" Signal in Cholangiocarcinoma
Sponsor: Hadassah Medical Organization
Summary
The investigators found an inverse relationship between CD24 and MiR-122 levels. Then the investigators found that CD24 that goes up with MiR-122 down makes macrophages unable to engulf the tumor cells. All this in mice. the investigators are interested in confirming this result in humans. Details of the preliminary results are attached to the submission of the research documents. the investigators will compare Cholangiocarcinoma tumors with other solid tumors, including liver tissue. The need to deepen understanding the investigators will also make a comparison between cancerous tissue and "normal" tissue adjacent to the tumor.
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2023-11-10
Completion Date
2026-10-28
Last Updated
2025-03-14
Healthy Volunteers
No
Conditions
Locations (1)
Hdassah Hospital
Jerusalem, Israel, Israel