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Protective Effect of RIPC Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)
Sponsor: Nanjing Medical University
Summary
Remote ischaemic pre-conditioning (RIPC) has been recognized as a low-cost, non-invasive intervention method by applying brief ischaemia and reperfusion on an arm or a leg. Previous studies have mainly focused on the organoprotective effects of RIPC in patients undergoing cardiac surgery. However, whether it has an organ-protecting effect is still highly debated. We aimed to determine whether intensive RIPC can prevent from negative inflammatory response and organ dysfunction as well as postoperative complications in patients undergoing cardiovascular surgery.
Official title: Protective Effect of Remote Ischemic Preconditioning (RIPC) Against Negative Inflammatory Response and Organ Dysfunction After Cardiovascular Surgery (Panda VII)
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
500
Start Date
2024-12-01
Completion Date
2025-12-31
Last Updated
2024-11-27
Healthy Volunteers
No
Interventions
Remote ischemic preconditioning (RIPC)
8 cycles of 5-minute inflation and 5-minute deflation on 2 upper and lower limbs with a blood pressure cuff
sham condition (control group)
8 cycles of 5-minute inflation to a pressure of 20 mm Hg followed by 5-minute cuff deflation.
Locations (1)
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China