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Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesions
Sponsor: October 6 University
Summary
Clinical assessment of the effectiveness of two treatment modalities (self-assembling peptide (P11-4) (alone or combined with fluoride) and resin infiltration) for treating white spot lesions
Official title: Clinical Outcome of Resin Infiltration Vs Self-Assembling Peptide (P11-4) in Treating White Spot Lesion - a Randomized Clinical Trial
Key Details
Gender
All
Age Range
7 Years - 14 Years
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2024-08-30
Completion Date
2025-02
Last Updated
2024-11-27
Healthy Volunteers
Yes
Conditions
Interventions
P11-4, a self-assembling peptide
rationally designed peptide, the monomers of which self-assemble into a biocompatible fibrillar scaffold that mimics the enamel matrix in response to particular environmental cues
P11-4, a self-assembling peptide with flouride
self assembling peptide with 500 ppm sodium fluoride
resin infilteration
Improvement of white spot lesions appearance by infiltration occurs due to a change in the refractive index since the refractive index of enamel (1.62-1.65) is different than that of air (1.00). Infiltration of the lesions with an infiltrate that has a refractive index of 1.52 is able to mask the lesion
Locations (1)
October 6 University
Cairo, Giza Governorate, Egypt