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APACA-Apheresis/acoustophoresis and Molecular Characterization of Prostate Cancer
Sponsor: Umeå University
Summary
The goal of this clinical study is to to improve diagnosis, follow-up and treatment for patients with disseminated prostate cancer. The aim is to isolate tumour cells before image diagnostic methods find the metastases. In addition, investigators will use this method to characterise the tumour cells at the "single-cell" level to understand both the metastasis process, early resistance mechanisms and thus find new treatment targets to optimise individualised treatment. Research subjects who either have disseminated disease at diagnosis or have recurrence after surgery (with minimal dissemination) will be included. A control population of young men without cancer will also be recruited to distinguish tumor-specific changes from normal signals using these new methods.
Key Details
Gender
MALE
Age Range
18 Years - 81 Years
Study Type
INTERVENTIONAL
Enrollment
130
Start Date
2020-09-29
Completion Date
2025-12-31
Last Updated
2024-11-29
Healthy Volunteers
Yes
Conditions
Interventions
Apheresis
Isolate tumor cells, immune cells, exosomes and cell free DNA from the blood by a clinically used method of whole blood volume filtration, apheresis, and subsequent separation of blood components using novel techniques, such as acoustophoresis and other experimental protocols.
Androgen deprivation therapy
Apheresis will be performed before initiation of systemic therapy (androgen deprivation therapy) and 4 weeks after. Androgen deprivation therapy is treatment as per clinical routine and not part of the protocol.
Anti androgen therapy
Apheresis will be performed before initiation of systemic therapy (anti androgen therapy). Anti androgen therapy is treatment as per clinical routine and not part of the protocol.
Locations (1)
Department of surgical and perioperative sciences, Umeå university
Umeå, Norrlands University Hospital, Sweden