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NOT YET RECRUITING
NCT06709716
PHASE4

Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy

Sponsor: Walter Reed National Military Medical Center

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn if preoperative nerve block (quadratus lumborum \[QL\] block) works to improve pain control during and after laparoscopic hysterectomy. The main questions it aims to answer are: Does QL block decrease the amount of narcotic medication needed during surgery? Does QL block decrease the amount of narcotic medication needed after surgery? Researchers will compare QL block to local injection of a numbing medication at each incision site (the current standard practice) to see if QL block works to decrease surgical pain. Participants will be randomly assigned to receive one of the two following interventions: 1. QL block before surgery with a long-acting numbing medicine (liposomal bupivacaine) and then injection of placebo (saline) at each incision site in the operating room. 2. QL block before surgery with placebo (saline) and then injection of local numbing medicine (bupivacaine) at each incision site in the operating room. Participants will also: * Visit the clinic/hospital for a pre-operative appointment, the surgical procedure, and a 4-6 week post-operative appointment (all standard visits even if not participating in research) * Complete a questionnaire electronically, or by phone, that takes \<10 minutes at the pre-operative appointment and on postoperative days 1, 3, 5, 14, and 4-6 weeks.

Official title: Impact of Preoperative Quadratus Lumborum Block on Postoperative Opioid Consumption After Laparoscopic Hysterectomy: a Double-blinded Randomized Controlled Trial

Key Details

Gender

FEMALE

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

76

Start Date

2024-12-01

Completion Date

2026-02

Last Updated

2024-11-29

Healthy Volunteers

No

Interventions

DRUG

Quadratus Lumborum Block (QLB)

Pre-operative quadratus lumborum block with liposomal bupivacaine

DRUG

Quadratus lumborum block

Pre-operative quadratus lumborum block with saline

DRUG

Local Anesthetic Solution

Intraoperative injection of 0.25% bupivacaine at each incision site

DRUG

Local Anesthetic Solution

Intraoperative injection of saline at each incision site.

Locations (1)

Walter Reed National Military Medical Center

Bethesda, Maryland, United States