Inclusion Criteria:
* All subjects or guardians must sign an informed consent form approved by the Ethics Committee in person before commencing any screening process;
* Be over 18 years of age, male or female;
* A diagnosis of SLE according to the 2012 systemic lupus international collaborating clinics(SLICC);
* The history of SLE prior to screening was at least 6 months, and the disease remained active at least 2 months after the use of a stable standard SLE regimen prior to screening:
1. Conventional regimens for SLE are corticosteroids and one or more immunomodulatory drugs over 6 months;
2. Oral corticosteroids must meet the following requirements:
* Prednisone (or equivalent) ≥7.5 mg/ day, and ≤60 mg/ day;
* There is no minimum daily dose requirement for corticosteroids when used in combination with immunosuppressants;
* At least 8 weeks of treatment prior to screening, and the dose must be kept stable for \> 2 weeks.
* SLEDAI-2000 score ≥8 during the screening period. Score ≥6 for SLEDAI-2000 clinical symptoms (except for low complement and/or anti-DS-DNA antibodies) if low complement and/or anti-DS-DNA antibody score is present;
* Women of childbearing age and all male patients must consent to use a effective contraception for at least 12 months after Meta10-19 infusion and until two consecutive PCR tests show no more CAR T cells in vivo;
* CD19 expression was positive by or flow cytometry ;
* Organ function:
1. Complete blood count (CBC) test \[the following criteria should be met within 24 hours prior to apheresis, and supportive treatment such as transfusion, platelet transfusion, cell growth factor (except recombinant erythropoietin) should be avoided within 7 days prior to detection\]
* Lymphocyte count ≥ 0.5×10\^9/L;
* Platelet count ≥ 25×10\^9/L;
* Hemoglobin ≥ 70.0 g/L
2. Blood Biochemistry:
* Serum creatinine (Scr) ≤ 1.5 x ULN, or
* endogenous creatinine clearance ≥ 40 mL/min (using Cockcroft-Gault formula);
* alanine aminotransferase (ALT) ≤ 2.5 x ULN;
* aspartate aminotransferase (AST) ≤ 2.5 ×ULN;
* Total bilirubin (TBIL) ≤ 2 ×ULN; Subjects with total bilirubin \< 3 × ULN and direct bilirubin \< 1.5× ULN with Gilbert-.Meulengracht syndrome could be included;
* Serum lipase and amylase ≤ 1.5×ULN;
* Alkaline phosphatase (ALP) ≤ 2.5 ×ULN.
3. Pulmonary function: ≤CTCAE grade 1 dyspnea and oxygen saturation of blood (SaO2) \> 91% in indoor air environment..
* Hemodynamic stability was determined by echocardiography or multichannel radionuclide angiography (MUGA) and LVEF ≥45%.
Exclusion Criteria:
* Prior to screening, other lupus crises, such as active central nervous system lupus, severe myocardial damage, severe lupus pneumonia or pulmonary hemorrhage, severe lupus hepatitis, and severe vasculitis.
* Clinically significant central nervous system diseases or pathological changes not caused by lupus prior to screening, including but not limited to: cerebrovascular accident, aneurysm, epilepsy, convulsions/convulsions, aphasia, stroke, severe brain injury, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome, or psychosis.
* History of major organ transplantation (e.g., heart, lung, kidney, liver) or hematopoietic stem cell/bone marrow transplantation.
* IgA deficiency was present during screening (serum IgA level \< 10 mg/dL).
* Other conditions that the investigator considered should not be enrolled in this clinical study.
