Clinical Research Directory

Inclusion Criteria: * Age \>18 years * Verified diagnosis of FSHD type 1, based on the clinical criteria established by Padberg et al. (1991) (22). * Category A or B of the four clinical categories according to the Comprehensive Clinical Evaluation Form (23), these patients have the most peculiar signs of the disease * A CIS-fatigue score of ≥ 35 * Owning of and being able to use a smartphone * Preserved ability to ambulate at the time of the selection * No pulmonary or cardiological involvement, that could interfere with physical training. * Absence of central or peripheral nervous system involvement as from neurological history and physical assessment * Absence of limb contractures and tendon retractions Exclusion Criteria: * Use of beta-blocker medication * Presence of additional diseases likely to interfere with the measurements * Psychological-psychiatric disorders * A musculoskeletal injury that impairs exercising * Scoliosis that impairs training * Recent adjustment of any medications or medications that may impact fatigue or taking stimulants for fatigue (e.g., Modafinil, amantadine) * Current participation in another clinical investigation of a medical device or a drug; or has participated in such a study within 30 days prior to this study * Pregnant women * Patient incapable of understanding the purpose and conditions of the study, incapable of giving consent or using the app * Patient deprived of liberty or patient under guardianship