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Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma
Sponsor: International Extranodal Lymphoma Study Group (IELSG)
Summary
Histological transformation in Splenic Marginal Zone Lymphoma (t-SMZL) represents an unmet clinical and biological need, invariably associated with poor prognosis and reduced overall survival. At the present time, there are no recommended treatments intended specifically to t-SMZL and little is known about t-SMZL genetic complexity. The aim of this study is to provide information that will help clinicians to better understand the complexity of the disease. The information gained from this study will also lead to more specific and effective treatment for patients with t-SMZL.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-10-13
Completion Date
2029-03
Last Updated
2026-01-16
Healthy Volunteers
No
Locations (7)
Columbia University
New York, New York, United States
Universitz Hospitals Leuven
Leuven, Belgium
Hôpital Saint Louis
Paris, France
Fondazione IRCCS Policlinico San Matteo
Pavia, Italy
Hospital Clínic de Barcelona
Barcelona, Spain
Oncology Institute of Southern Switzerland
Bellinzona, Switzerland
University Hospitals Dorset
Bournemouth, United Kingdom